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This nerve affects our balance and hearing by sending signals to the brain. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . Pycnogenol is considered possibly safe when taken orally or when applied topically as a cream or ointment. While pine bark extract is thought to be safe for children, they should only take it for a few weeks at a time. For children with ADHD, research suggests that symptoms start to return after about a month without taking maritime pine, so taking periodic breaks shouldnt make it any less effective. Forty-seven Japanese men with mild erectile dysfunction were given supplementation L-arginine and French maritime pine bark extract over a period of time. They were treated with 200 mg of Pycnogenol daily or with placebo. (4). It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. As I mentioned, pine bark extract is superior when it comes to antioxidants. Some pycnogenol supplements are mixed with other antioxidants, such as vitamin C. Pine bark extracts other than pycnogenol are also sold. Natural Factors Pycnogenol 25mg 60 Veggie Caps. In a clinical trial of 116 women, Pycnogenol (60 mg/day) reduced menstrual pain and the need for additional painkillers, taken over 2 cycles. We avoid using tertiary references. 4. It can also stabilize mast cells, which release histamine and trigger allergic reactions. However, healthy people are not immune and can also develop mild infections, in particular after being in improperly chlorinated hot tubs or swimming pools. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . Animal studies have found that gotu kola makes it harder . In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. Certain studies used combination products, so its unknown what the contribution of Pycnogenol itself was. American Cancer Society: "Pine Bark Extract.". In another trial, a combination supplement (Pycnogenol 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) improved erectile dysfunction and sexual satisfaction in men after 8 weeks. The crew fell extremely ill from scurvy, an extreme lack of vitamin C. Cartiers crew crossed paths with a Quebec Indian who encouraged them to drink a tea made from pine bark and needles. These antioxidants scavenge those damaging free radicals in an effort to eliminate them, ultimately preventing disease. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. There is insufficient evidence to support the use of Pycnogenol for any of the uses listed below. Discover what the research says about elimination diets, foods to eat, and more. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. Required fields are marked *. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. They include: We need more research to know for sure if pycnogenol helps treat these conditions. After stopping Pycnogenol for one month, symptoms Enzogenol also may reduce mental fatigue and sleep problems [82]. That said, there are some instances where this extract may possibly be effective. It also may increase the activity of genes that make collagen and hyaluronic acid in the body [64]. Based on another study of 6 trained and 7 untrained people, an antioxidant combination product containing Pycnogenol (Lactaway) may increase endurance. For most people, pine bark extract doesn't cause any side effects. More research is needed to see how this supplement affects all of these conditions. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. Its likely that muscle recovery time improved as well due to the high antioxidants pine bark extract contains. DOI: Marini A, et al. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. Possible side effects . Take Helpful Supplements. Pine bark extract has been studied regarding its relationship to exercise performance, oxidative stress and inflammation to body that has been imposed by exercise. They were given Pycnogenolfor a period of 10 days. Dizziness. Neuroprotective effect of Pycnogenol® following traumatic brain injury. Pycnogenol; Pycnogenol. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for . The . Pycnogenol (up to 200 mg/day) may improve asthma and reduce inflammatory asthma markers in the blood, leukotrienes, after 4 weeks, according to a randomized placebo-controlled trial of 26 asthma patients [14]. There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. It does this by improving the time it takes the body to reach a fatigued state through increased serum NAD+ levels. Although these may still be high quality, the active compounds are more likely to vary. In a study of 50 overweight people, a combination product (Pycnogenol, Madeglucyl, and starches called Glucaffect) reduced weight, BMI, blood glucose, and HbA1C after 8 weeks [30]. Pycnogenol effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women [Abstract]. In contrast, almost 20% of the participants on inhalers alone had to increase their dosage. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. 5) Inflammation and Allergies. $47.99. Pine bark distill has been studied regarding its relationship to exercise performance, oxidative stress and excitement to torso that has been imposed by exercise. Considering that about 1 of 3 adults in the U . It may cause side effects such as: Dizziness. Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). Not bad. Interactions. During week, five without, treatment, reduction of cramps was maintained in all three groups. After taking a break for one to two weeks, they can start taking it again for several weeks. Pycnogenol (100 mg/day) given to 44 older healthy people with high oxidative stress improved cognitive function, attention, mental performance, and reduced oxidative stress after 12 months [21]. For example, Enzogenol is an extract from a pine that grows in California and Mexico (Pinus radiata) that may have cognitive-enhancing effects. A 2021 review in the Arab Journal of Urology listed it first among "promising herbal remedies" for ED. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. Speak with your doctor before supplementing. All Pycnogenol-treated patients responded favorably in contrast to placebo treatment. Lower the risk of Alzheimer's disease. A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. DOI: Scheff SW, et al. Pine bark extract has been studied with regard to its ability to help diabetic patients. In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. There havent been enough studies yet to change practice protocols for treating children. (2013). Its quality is specified in the United States Pharmacopeia [3]. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. 4 Items . The combination of L-arginine and Pycnogenol may help in erectile dysfunction by boosting nitric oxide, which potentially could improve blood flow in men [66]. Is Garcinia Cambogia Safe for Weight Loss? Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. Treatment of ADHD with French maritime pine bark extract, Pycnogenol [Abstract]. New research shows . There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. Researchers suggest it may boost sustained attention, memory, executive functions, mood, and reduce oxidative stress [19]. 3. Results showed that one month of Pycnogenol led to a significant reduction of hyperactivity with improvement in attention and visual-motor coordination and concentration, as compared to no positive effects in the placebo group. In another study, Pycnogenol increased glutathione levels and total antioxidants after a month in children with ADHD [42, 43]. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. Sign Up for the Latest Health News and Tips, Home Food and Nutrition Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies. Video: Why You Need Zinc and Where to Find It. is a clickable link to peer-reviewed scientific studies. Pycnogenol is a patented extract of the French maritime pine bark (Pinus pinaster). A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. Pycnogenol suppresses inflammation and regulates the production of nitric oxide - a . This ensures that there is a healthy flow of blood to and from the heart. Studies have found that nattokinase thins the blood and dissolves accumulated solids in it. So it may not be safe for people with immune disorders, such as: It's not known if pycnogenol is safe for children or for women who are pregnant or breastfeeding. One study of 211 found that Pycnogenol may help prevent edema and ankle swelling from long flights [27]. The top benefits of nattokinase include the following: Regulate blood pressure. Vertigo. Remember to speak with a doctor before taking Pycnogenol. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli . In the following sections, well discuss the common forms and dosages of Pycnogenol that are commercially available. A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. But what makes this miracle ingredient so amazing? These benefits appeared to persist for some time even after stopping supplementation [72]. Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. Studies have found that supplementing with pycnogenol effectively strengthens the blood vessels, stabilizing blood pressure. (9), Related:Top 7 Benefits of Green Tea: The No. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. In this article, well summarize all the potential benefits and the scientific research surrounding pine bark extract and Pycnogenol. Our team aims to be not only thorough with its research, but also objective and unbiased. (11, 12), While both eliminate pain, the pine bark extract is a far better choice. This key chemical, proanthocyanidin, is also found in high concentrations in apples, cranberries, coca, grapes, and red wine. 2005-2023 Healthline Media a Red Ventures Company. Boost gastrointestinal health. A study of 68 people found that Pycnogenol, started 2 days prior to flying, may reduce the duration of jet lag symptoms [83]. Side effects. Also, its important to note that some of these studies were funded by Horphag Research, the original developers and exclusive marketers of Pycnogenol. nausea. Circulation and Jet Lag on Long Flights. High levels of both of these are considered risk factors for heart disease. Pycnogenol (100 mg/day) may reduce hay fever symptoms, according to a clinical trial of 39 people. Here are 12 benefits of ginkgo biloba. Here are the many health benefits believed to be possible with Pycnogenol: Now lets dive into the first condition it could help treat. from the bark of the French maritime pine tree. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. If you are taking blood thinners, do not take pine bark extract or Pycnogenol unless approved by your doctor. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. Research indicates that Pycnogenol provides an increase in survival performance of train athletes. All rights reserved. This is thought to be due to pine bark extracts ability to reduce oxidative stress and inflammation. Therefore, those who have autoimmune conditions could see their symptoms increase after taking it., Since Pycnogenol is used for so many conditions, doses can vary. In a study of 77 people with symptoms of Irritable Bowel Syndrome (IBS), Pycnogenol (150 mg/day) improved symptoms and reduced the frequency of attacks [77]. A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Mental function. Its best to check with your doctor about the dosage, based on the symptoms you have and other possible conditions, prior to taking either pine bark extract or Pycnogenol. Flavonoids and proanthocyanidins within these fruits can . But, as you know, going for the natural approach can make a huge difference in overall health. Tell your doctor about any supplements you're taking, even if they're natural. Some small studies suggest it may also protect against coronary artery disease and blood clots. A trial of 53 students found that pycnogenol may improve cognitive function, memory, attention, mood, and mental performance after 8 weeks [20]. Disease of the retina in the eye. A study with four groups of 30 patients each were studied: (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol and (4) medications only (control). It has many health benefits, and may help protect against several chronic conditions. Pycnogenol is the registered trademark brand name of French maritime pine bark extract. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. Chewing gum with Pycnogenol (2.5 mg/piece) for 4 weeks reduced bad breath and mouth bacteria in a trial of 22 people [57]. Taking pine bark extract also increases the blood . We take a look at what the science actually says. In a study of 100 healthy women mostly in their early 40s with mild sexual dysfunction, a combination product with Pycnogenol (Lady Prelox) improved sexual function over 8 weeks [74]. Diabetic retinopathy is a type of eye injury caused by complications from diabetes. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. Joe Cohen flipped the script on conventional and alternative medicine and it worked. Pycnogenol: A miracle component in reducing ageing and skin disorders. Pine bark extract comes from the inner bark of the Pinus pinaster tree, most commonly found in Europe. Dr. Eric L. Zielinski is a sought-after natural . Pycnogenol acts as a sustained-release formulation. If a blood clot blocks the normal blood flow, it is known as thrombosis. Several studies show how Pycnogenol helps block platelet formation and thus helps prevent thrombosis. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. Due to its anti-inflammatory properties, luteolin is being researched as a potential complementary treatment for multiple . Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Help your body fight the effects of normal aging. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. Any medication that you take, including herbal supplements, comes with certain risks. Staves Off Infections. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. If you choose to use Pycnogenol, follow the dosage instructions on the label. Helps Increase Athletic Performance. In a small/preliminary study of kids with asthma, pycnogenol helped improve symptoms. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. In clinical research, doses up to about 300 mg/day have been used for up to one year without major safety concerns [33, 37]. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . Score one for diabetes control and fewer risk factors for the heart. editor, The Gale Encyclopedia of Alternative Medicine, third edition, 2009. In addition to general healthy eating, some specific vitamins and minerals may help improve ADHD. Last medically reviewed on January 24, 2018. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. Our website services, content, and products are for informational purposes only. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. DOI: Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 50 to 450 milligrams of pine bark extract daily, Supplements During Pregnancy: Whats Safe and Whats Not, The ADHD Diet: What Works and What Does Not, Berberine A Powerful Supplement With Many Benefits, The Top Health Benefits of Prunes and Prune Juice, What to Know About Andrographis Supplements: Potential Benefits and Uses, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. Interesting activities, new dishes in restaurants, specialty ingredients, explanations of some netizens questions, etc.Hu Xuan is even helping Fatty s company s tourism manager, managing with Vice President Du Meixin, such as arranging guests reasonably.By the way.Dad, I want to tell you something.I plan to invest in the hotels and entertainment centers in the . In 1534, a French ship led by the famous explorer Jacques Cartier became stranded in ice near Quebec, Canada. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. DOI: Chowdhury WK, et al. Pycnogenol can help control blood pressure, which helps improve overall heart health. The same study showed that a single, 200-mg Pycnogenol dose remained effective over six days in preventing cigarette-induced enhanced platelet aggregation. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. are clickable links to medically peer-reviewed studies. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial.